Bioanalytical Scientist (LC-MS/MS)
TSRL, Inc
Ann Arbor, MI, USA
Posted on Apr 3, 2026
About TSRL
TSRL is a scientist-led preclinical CRO helping pharmaceutical, biotech, and academic innovators advance early drug candidates with confidence. Our team combines expertise in bioanalysis, PK/ADME, formulation development, toxicology, and translational strategy to generate high-quality data and guide smarter development decisions. For nearly four decades, TSRL has partnered with drug discovery teams to reduce development risk and accelerate promising therapeutics toward clinical evaluation.
We are seeking a Bioanalytical Scientist who will lead analytical assay development while contributing to the collaborative scientific environment of a small, multidisciplinary CRO.
Position Overview
The Bioanalytical Scientist will develop and apply analytical methods to quantify drugs and metabolites in biological matrices using LC-MS/MS and HPLC-UV. The role supports pharmacokinetic, efficacy, and exploratory toxicology studies for early-stage drug development programs as well as regulated bioanalysis for preclinical and clinical studies. Because TSRL is a small and highly collaborative organization, the ideal candidate demonstrates the ability to work across disciplines and contribute to multiple aspects of preclinical drug development.
Key Responsibilities
Bioanalytical Science (Primary Focus)
- Develop and validate bioanalytical methods for quantification of drugs and metabolites.
- Conduct GLP and non-GLP bioanalysis for preclinical and clinical studies.
- Perform dosing solution analysis and analytical support for preclinical PK and toxicology studies.
- Ensure high-quality analytical data and maintain appropriate documentation.
- Perform routine instrument maintenance and troubleshooting.
- Prepare and revise laboratory SOPs and technical documents.
- Author Method Validation Plans and Reports.
Collaborative Drug Development Support
- Work closely with PK/ADME scientists to support pharmacokinetic studies.
- Contribute analytical insights to preclinical efficacy and toxicology studies.
- Assist with interpretation of bioanalytical results within the broader development program.
- Participate in internal project discussions and client-facing scientific updates.
Optional Experience (Not Required)
Candidates with experience in any of the following areas are strongly encouraged to apply:
- PK/ADME studies or pharmacokinetic data interpretation
- In vitro ADME assays (microsomes, hepatocytes, permeability assays)
- Drug formulation or solubility optimization
- In vivo study procedures
- Early drug development strategy or translational science
Experience in these areas is a plus but not required.
Qualifications (Position aligned with experience)
- PhD (3-5 years of experience) or MS/BS (5+ years of experience) in Analytical Chemistry, Pharmaceutical Sciences, Pharmacology, or related field
- Strong expertise developing LC-MS/MS or HPLC analytical methods
- Deep understanding of bioanalytical method validation principles (M10 Guidance)
- Ability to work both independently and collaboratively in a fast-paced research environment
- Excellent communication and data interpretation skills
Why Join TSRL
- Work on innovative therapeutics across multiple disease areas
- Collaborate directly with biotech and pharmaceutical partners
- Gain exposure to multiple areas of drug development
- Join a scientist-driven, collaborative organization where your work directly impacts development decisions
- TSRL, Inc. offers a competitive compensation and benefits package including health and dental insurance, a 401(K) plan, disability insurance, and life insurance. We also provide opportunities for professional development in a collaborative research environment.
Location
This role is based in Ann Arbor, Michigan, a leading research hub anchored by the University of Michigan and a growing biotech ecosystem.
📩 Interested candidates are encouraged to apply and help advance the next generation of therapeutics.